Hydrochloric Acid → HCID 59570996, compound

Participants

Reaction Steps

To a solution of (2R)-2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-N-[5-(2,2-dimethyl-1,3-dioxolan-4-yl)pyrazin-2-yl]-3-(tetrahydro-2H-pyran-4-yl)propanamide (150 mg) in THF (10 mL) was added 1 M hydrochloric acid at room temperature, followed by stirring at room temperature for 3 hours. After extraction with ethyl acetate, the organic layer was sequentially washed with saturated aqueous sodium bicarbonate and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and concentrated to obtain (2R)-2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-N-[5-(1,2-dihydroxyethyl)pyrazin-2-yl]-3-(tetrahydro-2H-pyran-4-yl)propanamide (133 mg) as a white amorphous substance.

Provenance & Evidence