Water → HCID 59571056, compound

Participants

Reaction Steps

To a suspension of (2E)-2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-N-(1-methyl-1H-pyrazol-3-yl)-3-[(1S)-3-oxocyclopentyl]acrylamide (140 mg) in ethanol (2 mL) was added sodium borohydride (12 mg) at 0° C., followed by stirring for 15 minutes. The reaction mixture was diluted with chloroform and the reaction was stopped with water. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and then concentrated to obtain (2E)-2-[3-cyclopropyl-4-(cyclopropylsulfonyl)phenyl]-3-[(1S)-3-hydroxycyclopentyl]-N-(1-methyl-1H-pyrazol-3-yl)acrylamide (140 mg) as a colorless amorphous substance.

Provenance & Evidence