HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2192961Generated: November 2, 2026
(2R)-1,1,1-trifluoro-3-methylbutan-2-amine → 9-bromo-1-chloro-N-[(1R)-2-methyl-1-(trifluoromethyl)propyl]benzo[c]-1,6-naphthyridin-6-amine
https://huagongshe.com/reaction/2192961
Participants
| Role | Name | HCID | Charge |
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| Reactant | (2R)-1,1,1-trifluoro-3-methylbutan-2-amine | HCID 40427081 | — |
| Reactant | 9-Bromo-1,6-dichlorobenzo[c]-1,6-naphthyridine | HCID 59375470 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 9-bromo-1-chloro-N-[(1R)-2-methyl-1-(trifluoromethyl)propyl]benzo[c]-1,6-naphthyridin-6-amine | HCID 59375530 | — |
Reaction Steps
To a solution of dried 9-bromo-1,6-dichlorobenzo[c]-1,6-naphthyridine (0.80 g, 2.46 mmol) in dioxane (16 mL) was added (2R)-1,1,1-trifluoro-3-methylbutan-2-amine (2.4 g, 17.2 mmol) and heated to 150° C. for 24-48 hrs. The reaction was concentrated to dryness to give 9-bromo-1-chloro-N-[(1R)-2-methyl-1-(trifluoromethyl)propyl]benzo[c]-1,6-naphthyridin-6-amine. LRMS (ESI) calc'd for (C17H15BrClF3N3) [M+H]+, 432.0; found 432.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08329722B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-ab350e9e1cfd4f7882bee4dcac713165 |
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| Source note | uspto-grants-2012_12 |
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