Methanol → HCID 59398348, compound

Participants

Reaction Steps

To 1 mL of a methanol solution containing 66 mg of tert-butyl(2-(2-thienylthio)ethyl)(1-(trifluoroacetyl) piperidin-4-yl)carbamate, 0.2 mL of water was added, and 32 mg of potassium carbonate was added under cooling with ice, and the mixture was stirred at a room temperature for 20 minutes. Thereto was added 0.5 mL of methanol, and the mixture was stirred at room temperature for 1 hour and 10 minutes. The reaction mixture was added with 0.6 mL of tetrahydrofuran, and stirred for 10 minutes, and the solvent was removed under reduced pressure. The residue thus obtained was added with ethyl acetate and water. The organic layer was separated, washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 43 mg of a colorless oily substance, tert-butyl(piperidin-4-yl)(2-(2-thienylthio)ethyl)carbamate.

Provenance & Evidence