8-(2-(Benzyloxy)ethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile → 8-(2-Hydroxyethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile

Participants

Reaction Conditions

Reaction Steps

To 10 mL of an ethanol solution containing 1.0 g of 8-(2-(benzyloxy)ethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile, 0.50 g of 10% palladium-carbon was added at room temperature, and the mixture was stirred at 40 to 45° C. for 1 hour and 30 minutes under a hydrogen atmosphere. The insoluble material filtered off, and the solvent was removed under reduced pressure to obtained 0.80 g of a colorless oily substance, 8-(2-hydroxyethyl)-1,4-dioxaspiro[4.5]decane-8-carbonitrile.

Provenance & Evidence