Hydrogen chloride-ethyl acetate → 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-4-methylquinolin-2(1H)-one hydrochloride

Participants

Reaction Steps

To 5 mL of an ethyl acetate solution containing 139 mg of 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-4-methylquinolin-2(1H)-one, 0.3 mL of 4.0 mol/L hydrogen chloride/ethyl acetate was added, stirred at the same temperature for 10 min, and the resulting solid was filtered to give 117 mg of 1-(2-(1-(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)piperidin-4-ylamino)ethyl)-7-methoxy-4-methylquinolin-2(1H)-one hydrochloride as a pale yellow solid.

Provenance & Evidence