Sodium Bicarbonate → HCID 59397847, compound

Participants

Reaction Conditions

Reaction Steps

95 mg of 1-(1,3-dioxolan-2-ylmethyl)-6-methoxyquinolin-2(1H)-one was dissolved in 1.5 mL of 67% aqueous trifluoroacetic acid solution, and stirred at room temperature for 18 hours, at 40° C. for 6.5 hours, further at room temperature for 15 hours. After the reaction mixture was alkalized by adding aqueous saturated sodium hydrogen carbonate solution, it was extracted with ethyl acetate. The organic layer was washed with aqueous saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to give (6-methoxy-2-oxoquinolin-1(2H)-yl)acetaldehyde as a yellow oil.

Provenance & Evidence