1,4-Dioxane hydrochloride → HCID 67538397, compound

HRID 2193319Notes

Reaction equation

HRID 2193319 reaction equation
C(OC(=O)[N:7]([CH2:33][C:34]1[CH:43]=[CH:42][C:37]2[O:38][CH2:39][CH2:40][O:41][C:36]=2[CH:35]=1)[CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:25]3[C:20](=[C:21]([NH:26][C:27]([NH:29][CH2:30][CH3:31])=[O:28])[CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][C:17]2=[O:32])[CH2:10][CH2:9]1)(C)(C)C.[ClH:45].O1CCOCC1>O1CCOCC1>[ClH:45].[CH2:30]([NH:29][C:27]([NH:26][C:21]1[CH:22]=[CH:23][CH:24]=[C:25]2[C:20]=1[CH:19]=[CH:18][C:17](=[O:32])[N:16]2[CH2:15][CH2:14][N:11]1[CH2:12][CH2:13][CH:8]([NH:7][CH2:33][C:34]2[CH:43]=[CH:42][C:37]3[O:38][CH2:39][CH2:40][O:41][C:36]=3[CH:35]=2)[CH2:9][CH2:10]1)=[O:28])[CH3:31]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59398068HCID 59398068, compound

Product 1

HCID 67538397HCID 67538397, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 55 mg of tert-butyl(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(5-(3-ethylureido)-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 3 mL of 1,4-dioxane and 1 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature for 3 hours. The resulting solid was filtered to give 26 mg of 1-ethyl-3-(1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)quinolin-2(1H)-on-5-yl)urea hydrochloride as a yellow solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-1270ee13ce264cc7baa7c4f5a8f9eaa0
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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