1,4-Dioxane hydrochloride → 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-5-(N-methylamino)quinolin-2(1H)-one hydrochloride

HRID 2193321Notes

Reaction equation

HRID 2193321 reaction equation
C(OC(=O)[N:7]([CH2:29][C:30]1[CH:39]=[CH:38][C:33]2[O:34][CH2:35][CH2:36][O:37][C:32]=2[CH:31]=1)[CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:25]3[C:20](=[C:21]([NH:26][CH3:27])[CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][C:17]2=[O:28])[CH2:10][CH2:9]1)CCC.[ClH:41].O1CCOCC1>O1CCOCC1>[ClH:41].[O:34]1[C:33]2[CH:38]=[CH:39][C:30]([CH2:29][NH:7][CH:8]3[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]4[C:25]5[C:20](=[C:21]([NH:26][CH3:27])[CH:22]=[CH:23][CH:24]=5)[CH:19]=[CH:18][C:17]4=[O:28])[CH2:10][CH2:9]3)=[CH:31][C:32]=2[O:37][CH2:36][CH2:35]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 86643189HCID 86643189, compound

Product 1

HCID 675401591-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-5-(N-methylamino)quinolin-2(1H)-one hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 60 mg of tent-butyl(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)(1-(2-(5-(N-methylamino)-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate, 3 mL of 1,4-dioxane and 1 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature for 3 hours. The resulting solid was filtered to give 30 mg of 1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)-5-(N-methylamino)quinolin-2(1H)-one hydrochloride as a yellow solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-8dcccb2ce99d4dbfabda5d8cc7b61468
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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