Chloroform → HCID 67539378, Verbindung

HRID 2193351Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2193351
C(Cl)(Cl)[Cl:2].[F:5][C:6]1[CH:7]=[C:8]([CH:32]=[CH:33][C:34]=1[CH3:35])[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=3)[N:22]=[CH:21][C:20]2=[O:31])[CH2:13][CH2:12]1.Cl.C(OCC)(=O)C>C(OCC)(=O)C>[ClH:2].[F:5][C:6]1[CH:7]=[C:8]([CH:32]=[CH:33][C:34]=1[CH3:35])[CH2:9][NH:10][CH:11]1[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][N:19]2[C:28]3[C:23](=[CH:24][CH:25]=[C:26]([O:29][CH3:30])[CH:27]=3)[N:22]=[CH:21][C:20]2=[O:31])[CH2:13][CH2:12]1

Komponenten

5

Edukt 3

HCID 6212ChloroformHCID 21866389Hydrogen chloride-ethyl acetateHCID 593982681-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one

Produkt 1

HCID 67539378HCID 67539378, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a mixed solution of 10 mL chloroform and 4 mL ethyl acetate containing 0.44 g of 1-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one, 2 mL of 4 mol/L hydrogen chloride/ethyl acetate was added, and stirred at room temperature. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 422 mg of 1-(2-(4-(3-fluoro-4-methylbenzylamino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a brown solid.

Aufarbeitung

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-f371ef250aac4a5b80c173b11e9db1dc
Quelldatensatz
uspto-grants-2012_12
Patentnummer
US08329694B2

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