1,4-Dioxane hydrochloride → HCID 67540170, compound

HRID 2193379Notes

Reaction equation

HRID 2193379 reaction equation
C(OC(=O)[N:7]([CH:19]1[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][N:27]2[C:36]3[C:31](=[C:32]([Cl:37])[CH:33]=[CH:34][CH:35]=3)[CH:30]=[CH:29][C:28]2=[O:38])[CH2:21][CH2:20]1)[CH2:8][C:9]1[CH:18]=[CH:17][C:12]2[O:13][CH2:14][CH2:15][O:16][C:11]=2[CH:10]=1)(C)(C)C.Cl.O1CCOCC1>O1CCOCC1>[ClH:37].[Cl:37][C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:31]=1[CH:30]=[CH:29][C:28](=[O:38])[N:27]2[CH2:26][CH2:25][N:22]1[CH2:23][CH2:24][CH:19]([NH:7][CH2:8][C:9]2[CH:18]=[CH:17][C:12]3[O:13][CH2:14][CH2:15][O:16][C:11]=3[CH:10]=2)[CH2:20][CH2:21]1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 59398043HCID 59398043, compound

Product 1

HCID 67540170HCID 67540170, compoundYield 129.1%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To 0.28 g of tert-butyl(1-(2-(5-chloro-2-oxoquinolin-1(2H)-yl)ethyl)piperidin-4-yl)(2,3-dihydro-1,4-benzodioxin-6-ylmethyl)carbamate, 6 mL of 1,4-dioxane and 2 mL of 4 mol/L hydrogen chloride/1,4-dioxane were added, and stirred at room temperature overnight. The resulting solid was filtered to give 0.16 g of 5-chloro-1-(2-(4-((2,3-dihydro-1,4-benzodioxin-6-ylmethyl)amino)piperidin-1-yl)ethyl)quinolin-2(1H)-one hydrochloride as a white solid.

Workup

  1. filtrationThe resulting solid was filtered

Sources & evidence

ORD record
ord-6f1bd94f913c4542851a363516cb6731
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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