Hydrogen chloride-ethyl acetate → HCID 67538545, compound

HRID 2193381Notes

Reaction equation

HRID 2193381 reaction equation
C(OC(=O)[NH:7][C:8]1[CH:13]=[C:12]([CH2:14][NH:15][CH:16]2[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][N:24]3[C:33]4[C:28](=[CH:29][CH:30]=[C:31]([O:34][CH3:35])[CH:32]=4)[N:27]=[CH:26][C:25]3=[O:36])[CH2:18][CH2:17]2)[CH:11]=[CH:10][C:9]=1[CH3:37])(C)(C)C.[ClH:39].C(OCC)(=O)C>>[ClH:39].[NH2:7][C:8]1[CH:13]=[C:12]([CH:11]=[CH:10][C:9]=1[CH3:37])[CH2:14][NH:15][CH:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][N:24]2[C:33]3[C:28](=[CH:29][CH:30]=[C:31]([O:34][CH3:35])[CH:32]=3)[N:27]=[CH:26][C:25]2=[O:36])[CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 59397957HCID 59397957, compound

Product 1

HCID 67538545HCID 67538545, compound

Procedure

To 0.28 g of tert-butyl(5-(((1-(2-(7-methoxy-2-oxoquinoxalin-1(2H)-yl)ethyl)piperidin-4-yl)amino)methyl)-2-methylphenyl)carbamate, 30 mL of 4 mol/L hydrogen chloride/ethyl acetate solution was added, and stirred at room temperature for 41 hours. The solvent was removed under reduced pressure, ethyl acetate was added and the resulting solid was filtered to give 0.26 g of (1-(2-(4-((3-amino-4-methylbenzyl)amino)piperidin-1-yl)ethyl)-7-methoxyquinoxalin-2(1H)-one hydrochloride as a yellow solid.

Workup

  1. customThe solvent was removed under reduced pressure, ethyl acetate
  2. additionwas added
  3. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-fe32863da31e43e1a867f664550540ef
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

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