Hydrogen chloride-ethyl acetate → HCID 67539282, compound

HRID 2193398Notes

Reaction equation

HRID 2193398 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[ClH:36].C(OCC)(=O)C>C(Cl)(Cl)Cl>[ClH:36].[CH3:1][O:2][C:3]1[CH:12]=[C:11]2[C:6]([N:7]=[CH:8][C:9](=[O:35])[N:10]2[CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([NH:21][CH2:22][C:23]3[CH:32]=[C:31]([O:33][CH3:34])[C:26]4[O:27][CH2:28][CH2:29][O:30][C:25]=4[CH:24]=3)[CH2:17][CH2:16]2)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 593983727-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one

Product 1

HCID 67539282HCID 67539282, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

To 10 mL of a chloroform solution containing 478 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one, 1 mL of 4 mol/L hydrogen chloride/ethyl acetate and 5 mL of chloroform were added, and stirred at room temperature for 10 min. The solvent was removed under reduced pressure, ethyl acetate was added, and the resulting solid was filtered to give 429 mg of 7-methoxy-1-(2-(4-((8-methoxy-2,3-dihydro-1,4-benzodioxin-6-yl)methylamino)piperidin-1-yl)ethyl)quinoxalin-2(1H)-one hydrochloride as a dark brown powder.

Workup

  1. additionwere added
  2. customThe solvent was removed under reduced pressure, ethyl acetate
  3. additionwas added
  4. filtrationthe resulting solid was filtered

Sources & evidence

ORD record
ord-ce5f78bfaa4d4b4c816cba9ab09cbd27
Source dataset
uspto-grants-2012_12
Patent number
US08329694B2

Reaction notes

Loading…