HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (2-Isocyanatocyclopropyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Phenylcyclopropane-1-carboxylic acid | HCID 70323 | — |
| Reactant | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | (2-Isocyanatocyclopropyl)benzene | HCID 582709 | 81.5% |
Reaction Steps
To a solution of 2-phenylcyclopropanecarboxylic acid (1.0 g, 6.17 mmol) in dry toluene (20 mL) was added triethylamine (934 mg, 9.26 mmol) and DPPA (2.0 g, 7.41 mmol) under N2, and the reaction mixture was refluxed for 3 h. The solution was concentrated to give (2-isocyanatocyclopropyl)benzene (800 mg), which was used for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329897B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-a30d8d5669dc4f71a805388954e5466c |
| Source note | uspto-grants-2012_12 |