HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2193560Generated: November 1, 2026
Chlorotrimethylsilane → HCID 58916239, compound
https://huagongshe.com/reaction/2193560
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 7-Chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid | HCID 11055142 | — |
| Reactant | HCID 67273834 | HCID 67273834 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 58916239 | HCID 58916239 | — |
Reaction Steps
A suspension of 100 mg N-{(5S)-3-[3-fluoro-4-(piperidin 4-ylamino)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}acetamide (0.28 mmol), 80.66 mg 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (0.28 mmol), 0.108 ml trimethylchlorosilane (0.84 mmol) and 0.16 ml triethylamine (1.12 mmol) in 2 ml DMSO was heated under stirring in a micro wave oven at 150° C. for 7 min. The DMSO was evaporated, the residue was purified by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329908B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-cdc470f4ceba49abb49eb95cd52a48da |
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| Source note | uspto-grants-2012_12 |
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