HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-methyl-1H-imidazole → 7-Chloro-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-methyl-1H-imidazole | HCID 1277653 | — |
| Reactant | 7-chloro-2-(1-methyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine | HCID 22143563 | — |
| Product | 7-Chloro-2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridine | HCID 59424524 | — |
Reaction Steps
Following the procedure described for compound 7 (example 2, step 3) but substituting 2-bromo-1-methyl-1H-imidazole for 4-bromo-1-methyl-1H-imidazole [a) Begtrup, M.; Larsen, P.; Acta Chem. Scand. 44, 10:1990:1050-1057, b) Begtrup, M.; Bull. Soc. Chim. Belg.; 97; 8-9; 1988; 573-598, c) Begtrup, M.; Larsen, P.; Chem. Pharm. Bull. 42, 9; 1994; 1784-1790.], title compound 10 was obtained as an off-white solid (29% yield). MS (m/z): 250.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329726B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-59dad4c7395a409293b854058bb5e9c1 |
| Source note | uspto-grants-2012_12 |