HuagongsheHuagongshe Chemistry Print Report · For research reference only
N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide → N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N1-(3-fluoro-4-(thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | HCID 45488043 | — |
| Reactant | 3-Fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)benzenamine | HCID 59424507 | — |
| Product | N1-(3-fluoro-4-(2-(1-methyl-1H-imidazol-4-yl)thieno[3,2-b]pyridin-7-yloxy)phenyl)-N3-phenylmalonamide | HCID 44565164 | — |
Reaction Steps
Following the procedure described for compound 5a (example 1, step 5) but substituting amine 9 for compound 12, title compound 5c was obtained as a white solid (78% yield). MS (m/z): 502.0 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329726B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8882ec073d834cb3a3ef6683eb7aeb79 |
| Source note | uspto-grants-2012_12 |