HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-nitrophenol → 1-(1-Ethyl-4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1H-imidazol-2-yl)-N,N-dimethylmethanamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-nitrophenol | HCID 9825 | — |
| Reactant | 1-(4-(7-Chlorothieno[3,2-b]pyridin-2-yl)-1-ethyl-1H-imidazol-2-yl)-N,N-dimethylmethanamine | HCID 58790245 | — |
| Reactant | 2-(1-Ethyl-1H-imidazol-4-yl)-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine | HCID 66649032 | — |
| Product | 1-(1-Ethyl-4-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)-1H-imidazol-2-yl)-N,N-dimethylmethanamine | HCID 58790400 | 48% |
Reaction Steps
Starting from the chloride 112 and 2-fluoro-4-nitrophenol and following the same procedure as described above for the synthesis of compound 14 (scheme 4), title compound 113 was obtained as yellow solid in 48% yield. MS (m/z): 442.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329726B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-6e9dfcba1d4c405ab9cafed467f1c8b7 |
| Source note | uspto-grants-2012_12 |