P-Anisidine → 1-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acid

HRID 2193725Notes

Reaction equation

HRID 2193725 reaction equation
[C:1]1([NH:7][C:8]([C:10]2([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:16][O:17]C1C=CC(N)=CC=1>>[CH3:16][O:17][C:6]1[CH:5]=[CH:4][CH:3]=[CH:2][C:1]=1[NH:7][C:8]([C:10]1([C:13]([OH:15])=[O:14])[CH2:11][CH2:12]1)=[O:9]

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 190968711-(Phenylcarbamoyl)cyclopropanecarboxylic acid

Product 1

HCID 550353091-(2-Methoxyphenylcarbamoyl)cyclopropanecarboxylic acidYield 68%

Procedure

Following the procedure described above for compound 161 (scheme 45), but replacing aniline for 4-methoxyaniline, title compound 175 was obtained in 68% yield. M/S (m/z): 236.0 (M+H).

Sources & evidence

ORD record
ord-917bfe3623b644ef88443d819059989c
Source dataset
uspto-grants-2012_12
Patent number
US08329726B2

Reaction notes

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