Toluene → Retinol

Participants

Reaction Steps

To a vial was added retinol in toluene (54% retinol; 1.852 g; 1.0 g retinol; 3.49 mmol), ricinoleic acid (80%; 1.250 g; 4.19 mmol; 1.2 equiv), and Novozym 435 (1 g). The mixture was sealed and stirred at room temperature for 21 h to afford 83% conversion of retinol to 1b.

Provenance & Evidence