Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | (2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid chloride | HCID 86584140 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 44512057 | HCID 44512057 | — |
Reaction Steps
Preparation: 30 g of Naproxen chloride are dissolved in 120 g of dichloromethane. This solution is cooled at 0° C. and a solution of 14.5 g of 1-chloro-3-buthanol in 100 g of dichloromethane is added dropwise in 2 hours. After a completion time of 3 hours at 0° C., 60 g of water are added and is the mixture is stirred for 10 hours. After phase separation, 60 g of water are added to organic phase and the mixture is stirred for 10 hours. After phase separation, the organic phase is concentrated to 120 mL and 4.5 g of potassium carbonate are added. The mixture is refluxed at about 40° C. for 4 hours. After filtration and vacuum concentration, an oil is obtained (HPLC purity 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08329937B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-b99215b89e3142c49c7c81df1457f4ee |
|---|
| Source note | uspto-grants-2012_12 |
|---|
