HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → (S)-1-benzyl-3-[1-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl]urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | 1-(S)-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl amine hydrobromide | HCID 66694935 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | (S)-1-benzyl-3-[1-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl]urea | HCID 59464668 | 96% |
Reaction Steps
To a solution of 1-(S)-(4-ethylthiazol-2-yl)-2-(4-nitrophenyl)ethyl amine hydrobromide, 3, (0.360 g, 1 mmol) and Et3N (0.42 mL, 3 mmol) in 10 mL CH2Cl2 is added benzyl isocyanate (0.12 mL, 1 mmol). The mixture is stirred at room temperature for 18 hours. The product is isolated by filtration to afford 0.425 g (96% yield) of the desired product which is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329916B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d97ba59aec964d6d8adc7a7fe12d2855 |
| Source note | uspto-grants-2012_12 |