反应详情

There are introduced into a 670 litre reactor 12.6 kg of 5% palladium-on-carbon in toluene, which is heated at reflux; then 96.1 kg of (7-methoxy-3,4-dihydro-1-naphthyl)acetonitrile dissolved in toluene are added and also 63.7 kg of allyl methacrylate. The reaction is continued at reflux and is monitored by vapour phase chromatography. When all the starting substrate has disappeared, the reaction mixture is cooled to ambient temperature and then filtered. After evaporating off the toluene, the solid residue obtained is recrystallised from an ethanol/water (80/20) mixture to yield the title product in a yield of 91% and with a chemical purity of more than 99%.

1. temperatureis heated
2. temperatureat reflux
3. additionare added
4. temperatureat reflux
5. filtrationfiltered
6. customAfter evaporating off the toluene
7. customthe solid residue obtained
8. customis recrystallised from an ethanol/water (80/20) mixture