Benzenesulfonyl chloride → 1-Benzenesulfonyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

HRID 2193997Notes

Reaction equation

[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:11]([O:13][C:14]([C:16]1([CH2:22][CH2:23][O:24][CH3:25])[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)=[O:15])[CH3:12]>>[CH2:11]([O:13][C:14]([C:16]1([CH2:22][CH2:23][O:24][CH3:25])[CH2:17][CH2:18][N:19]([S:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)(=[O:9])=[O:8])[CH2:20][CH2:21]1)=[O:15])[CH3:12]

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 667870971-Benzenesulfonyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Procedure

This material was prepared in analogy to example 1 step C) from benzenesulfonyl chloride (0.115 g), 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (0.14 g) as a brown oil (0.13 g). MS (ESI): 356.1 (MH+).

Sources & evidence

ORD record: ord-b6f8ddc7372f4c3c8cd3451d7ac6cb2e
Source dataset: uspto-grants-2012_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08329904B2

Reaction notes

Loading…