5-Amino-2-chloropyridine → HCID 49801957, compound

Participants

Reaction Steps

This material was prepared in analogy to example 1 step D) from 1-benzenesulfonyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (0.2 g), dimethylaluminium chloride in heptane (0.9 molar, 1.88 ml) and 5-amino-2-chloro-pyridine (0.145 g) to give the desired 8-benzenesulfonyl-2-(6-chloro-pyridin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one (0.012 g) as a white solid. MS (ESI): 406.1 (MH+).

Provenance & Evidence