HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxypyridazin-3-amine → 8-Benzenesulfonyl-2-(6-methoxy-pyridazin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxypyridazin-3-amine | HCID 81673 | — |
| Reactant | Dimethylalumanylium chloride | HCID 16686359 | — |
| Reactant | 1-Benzenesulfonyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 66787097 | — |
| Solvent | Heptane | HCID 8900 | — |
| Product | 8-Benzenesulfonyl-2-(6-methoxy-pyridazin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 49801962 | 14.1% |
Reaction Steps
This material was prepared in analogy to example 1 step D) from 1-Benzenesulfonyl-4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (0.15 g), dimethylaluminium chloride in heptane (0.9 molar, 0.71 ml) and 3-amino-6-methoxypyridazine (0.069 g) to give the desired 8-benzenesulfonyl-2-(6-methoxy-pyridazin-3-yl)-2,8-diaza-spiro[4.5]decan-1-one (0.024 g) as a white solid. MS (ESI): 403.146 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0965a8fb450c41cd9036043bc7d5d5a2 |
| Source note | uspto-grants-2012_12 |