4-Ethylaniline → HCID 49801351, compound
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:25])([F:24])[CH2:18][CH2:19][S:20](Cl)(=[O:22])=[O:21].[CH2:26]([C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1)[CH3:27]>>[CH2:26]([C:28]1[CH:34]=[CH:33][C:31]([N:32]2[CH2:13][CH2:12][C:6]3([CH2:7][CH2:8][N:9]([S:20]([CH2:19][CH2:18][C:17]([F:25])([F:24])[F:16])(=[O:22])=[O:21])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:30][CH:29]=1)[CH3:27]Participants
4
Procedure
Light yellow solid. MS (ESI): 419.16 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 3,3,3-trifluoro-propane-1-sulfonyl chloride and 4-ethyl-aniline.
Sources & evidence
- ORD record
- ord-63d0e05350e947ac99bdd98b9d821ded
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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