4-Ethylaniline → 8-(2,2-Dimethyl-propane-1-sulfonyl)-2-(4-ethyl-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][C:17]([CH3:24])([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[CH2:25]([C:27]1[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=1)[CH3:26]>>[CH3:16][C:17]([CH3:24])([CH3:23])[CH2:18][S:19]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:31]([C:30]3[CH:32]=[CH:33][C:27]([CH2:25][CH3:26])=[CH:28][CH:29]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:21])=[O:20]Participants
4
Procedure
Light brown solid. MS (ESI): 415.2 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2,2-dimethylpropane-1-sulfonyl chloride and 4-ethyl-aniline.
Sources & evidence
- ORD record
- ord-f485b19ece8f4bc595340bca1c71431c
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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