3,3-Dimethylbutanoyl chloride → HCID 49802794, compound

HRID 2194026Notes

Reaction equation

HRID 2194026 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[C:16]([CH2:20][C:21](Cl)=[O:22])([CH3:19])([CH3:18])[CH3:17].[CH:24]1([C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[CH:33]=[CH:32][C:30]([N:31]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([C:21](=[O:22])[CH2:20][C:16]([CH3:19])([CH3:18])[CH3:17])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:29][CH:28]=2)[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 815143,3-Dimethylbutanoyl chlorideHCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49802794HCID 49802794, compound

Procedure

Light yellow solid. MS (ESI): 369.25 (MH+). This example was prepared in analogy to example 7 step A) to B) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), tert-butyl acetyl chloride and 4-cyclopropyl-aniline.

Sources & evidence

ORD record
ord-92c7e81e95c94356bb3001f8d9afb54c
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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