Phenylmethanesulfonyl chloride → HCID 49802797, compound

HRID 2194029Notes

Reaction equation

HRID 2194029 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[C:16]1([CH2:22][S:23](Cl)(=[O:25])=[O:24])[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH:27]1([C:30]2[CH:36]=[CH:35][C:33]([NH2:34])=[CH:32][CH:31]=2)[CH2:29][CH2:28]1>>[CH:27]1([C:30]2[CH:36]=[CH:35][C:33]([N:34]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([S:23]([CH2:22][C:16]5[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=5)(=[O:25])=[O:24])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:32][CH:31]=2)[CH2:29][CH2:28]1

Participants

4

Reactant 3

HCID 74740Phenylmethanesulfonyl chlorideHCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49802797HCID 49802797, compound

Procedure

Light brown solid. MS (ESI): 425.19 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), phenyl-methanesulfonyl chloride and 4-cyclopropyl-aniline.

Sources & evidence

ORD record
ord-c7b02209c70742d8b26ef1a47b520a9d
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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