1-Propanesulfonyl chloride → HCID 49802798, compound

HRID 2194030Notes

Reaction equation

HRID 2194030 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH2:16]([S:19](Cl)(=[O:21])=[O:20])[CH2:17][CH3:18].[CH:23]1([C:26]2[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=2)[CH2:25][CH2:24]1>>[CH:23]1([C:26]2[CH:32]=[CH:31][C:29]([N:30]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([S:19]([CH2:16][CH2:17][CH3:18])(=[O:21])=[O:20])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:28][CH:27]=2)[CH2:25][CH2:24]1

Participants

4

Reactant 3

HCID 662791-Propanesulfonyl chlorideHCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49802798HCID 49802798, compound

Procedure

Off-white solid. MS (ESI): 377.19 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 1-propanesulfonyl chloride and 4-cyclopropyl-aniline.

Sources & evidence

ORD record
ord-38f0102f7edb461992855624cbac2694
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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