HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,3-Dimethylbutanoyl chloride → 8-(3,3-Dimethyl-butyryl)-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,3-Dimethylbutanoyl chloride | HCID 81514 | — |
| Reactant | 4-(2,2,2-Trifluoroethyl)aniline | HCID 14836858 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | 8-(3,3-Dimethyl-butyryl)-2-[4-(2,2,2-trifluoro-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 49802799 | — |
Reaction Steps
Off-white solid. MS (ESI): 411.22 (MH+). This example was prepared in analogy to example 7 step A) to B) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), tert.-butylacetyl chloride and 4-(2,2,2-trifluoroethyl)-aniline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-098cf3ac9400491e89efca0028add2d5 |
| Source note | uspto-grants-2012_12 |