4-(Trifluoromethoxy)aniline → HCID 49803069, compound

HRID 2194033Notes

Reaction equation

HRID 2194033 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][C:17]1[S:21][C:20]([S:22](Cl)(=[O:24])=[O:23])=[CH:19][CH:18]=1.[F:26][C:27]([F:37])([F:36])[O:28][C:29]1[CH:35]=[CH:34][C:32]([NH2:33])=[CH:31][CH:30]=1>>[CH3:16][C:17]1[S:21][C:20]([S:22]([N:9]2[CH2:8][CH2:7][C:6]3([C:4](=[O:5])[N:33]([C:32]4[CH:34]=[CH:35][C:29]([O:28][C:27]([F:26])([F:36])[F:37])=[CH:30][CH:31]=4)[CH2:13][CH2:12]3)[CH2:11][CH2:10]2)(=[O:24])=[O:23])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 124001125-Methylthiophene-2-sulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803069HCID 49803069, compound

Procedure

Off-white solid. MS (ESI): 475.07 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 5-methylthiophene-2-sulphonyl chloride and 4-(trifluoromethoxy)-aniline.

Sources & evidence

ORD record
ord-604bb38aa19e4a3d99182268c07ac14b
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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