2-Chlorobenzenesulfonyl chloride → Methanesulfonic acid 4-[8-(2-chloro-benzenesulfonyl)-1-oxo-2,8-diaza-spiro[4.5]dec-2-yl]-phenyl ester
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24].[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][S:35]([CH3:38])(=[O:37])=[O:36])=[CH:30][CH:29]=1>>[Cl:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:27]([C:28]3[CH:33]=[CH:32][C:31]([O:34][S:35]([CH3:38])(=[O:37])=[O:36])=[CH:30][CH:29]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:25])=[O:24]Participants
4
Procedure
Light brown solid. MS (ESI): 499.07 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chlorobenzenesulfonyl chloride and methanesulfonic acid 4-amino-phenyl ester (synthesis: S. Kobayashi, et al.; Synlett. 2000, p 883).
Sources & evidence
- ORD record
- ord-5679deb2a069430694dbcf582e92afed
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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