4-(Trifluoromethoxy)aniline → HCID 49803634, compound

HRID 2194045Notes

Reaction equation

HRID 2194045 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26].[F:31][C:32]([F:42])([F:41])[O:33][C:34]1[CH:40]=[CH:39][C:37]([NH2:38])=[CH:36][CH:35]=1>>[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:38]([C:37]3[CH:39]=[CH:40][C:34]([O:33][C:32]([F:31])([F:41])[F:42])=[CH:35][CH:36]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:27])=[O:26]

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803634HCID 49803634, compound

Procedure

Off-white solid. MS (ESI): 539.10 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and 4-(trifluoromethoxy)-aniline.

Sources & evidence

ORD record
ord-154e07da22ad469485400969eb1e6990
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…