1-Propanesulfonyl chloride, 2-methyl- → HCID 49803927, compound

HRID 2194052Notes

Reaction equation

HRID 2194052 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][CH:17]([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][S:32]([CH3:35])(=[O:34])=[O:33])=[CH:27][CH:26]=1>>[CH3:16][CH:17]([CH3:23])[CH2:18][S:19]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:24]([C:25]3[CH:30]=[CH:29][C:28]([O:31][S:32]([CH3:35])(=[O:34])=[O:33])=[CH:27][CH:26]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:21])=[O:20]

Participants

4

Reactant 3

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 19885019Phenol, 4-amino-, 1-methanesulfonateHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49803927HCID 49803927, compound

Procedure

Light brown solid. MS (ESI): 445.14 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-methyl-propane-1-sulfonyl chloride and methanesulfonic acid 4-amino-phenyl ester.

Sources & evidence

ORD record
ord-12825cbfee7248f8ae6816922fd2a555
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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