1-Propanesulfonyl chloride, 2-methyl- → HCID 49804217, compound

HRID 2194053Notes

Reaction equation

HRID 2194053 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][CH:17]([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[CH:24]1([C:27]2[CH:33]=[CH:32][C:30]([NH2:31])=[CH:29][CH:28]=2)[CH2:26][CH2:25]1>>[CH:24]1([C:27]2[CH:33]=[CH:32][C:30]([N:31]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([S:19]([CH2:18][CH:17]([CH3:23])[CH3:16])(=[O:21])=[O:20])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:29][CH:28]=2)[CH2:26][CH2:25]1

Participants

4

Reactant 3

HCID 1822361-Propanesulfonyl chloride, 2-methyl-HCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49804217HCID 49804217, compound

Procedure

Off-white solid. MS (ESI): 391.2 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-methyl-propane-1-sulfonyl chloride and 4-cylopropyl-aniline.

Sources & evidence

ORD record
ord-0a89c1e015e643098eb7ab07388e8df3
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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