4-Ethylaniline → HCID 49804221, compound

HRID 2194058Notes

Reaction equation

HRID 2194058 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[S:27](Cl)(=[O:29])=[O:28].[CH2:31]([C:33]1[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=1)[CH3:32]>>[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[S:27]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:37]([C:36]3[CH:38]=[CH:39][C:33]([CH2:31][CH3:32])=[CH:34][CH:35]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:29])=[O:28]

Participants

4

Reactant 3

HCID 115044-EthylanilineHCID 27366752-Chloro-4-(trifluoromethyl)benzenesulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49804221HCID 49804221, compound

Procedure

Light brown solid. MS (ESI): 501.12 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chloro-4-trifluoromethyl-benzenesulfonyl chloride and 4-ethyl-aniline.

Sources & evidence

ORD record
ord-3860cc8b784d48899bc939c33ca7c297
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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