4-(Trifluoromethoxy)aniline → HCID 49804514, compound

HRID 2194059Notes

Reaction equation

HRID 2194059 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[S:27](Cl)(=[O:29])=[O:28].[F:31][C:32]([F:42])([F:41])[O:33][C:34]1[CH:40]=[CH:39][C:37]([NH2:38])=[CH:36][CH:35]=1>>[Cl:16][C:17]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[CH:19][C:18]=1[S:27]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:38]([C:37]3[CH:39]=[CH:40][C:34]([O:33][C:32]([F:31])([F:41])[F:42])=[CH:35][CH:36]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:29])=[O:28]

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 27366752-Chloro-4-(trifluoromethyl)benzenesulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49804514HCID 49804514, compound

Procedure

White solid. MS (ESI): 557.07 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-chloro-4-trifluoromethyl-benzenesulfonyl chloride and 4-(trifluoromethoxy)-aniline.

Sources & evidence

ORD record
ord-4ced7e2929014371baaabfad87050531
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

Loading…