2-Trifluoromethylbenzenesulphonyl chloride → HCID 49804515, compound

HRID 2194060Notes

Reaction equation

HRID 2194060 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:29])([F:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24](Cl)(=[O:26])=[O:25].[CH:30]1([C:33]2[CH:39]=[CH:38][C:36]([NH2:37])=[CH:35][CH:34]=2)[CH2:32][CH2:31]1>>[CH:30]1([C:33]2[CH:39]=[CH:38][C:36]([N:37]3[CH2:13][CH2:12][C:6]4([CH2:7][CH2:8][N:9]([S:24]([C:19]5[CH:20]=[CH:21][CH:22]=[CH:23][C:18]=5[C:17]([F:29])([F:28])[F:16])(=[O:26])=[O:25])[CH2:10][CH2:11]4)[C:4]3=[O:5])=[CH:35][CH:34]=2)[CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 1366162-Trifluoromethylbenzenesulphonyl chlorideHCID 122539274-CyclopropylanilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49804515HCID 49804515, compound

Procedure

Off-white solid. MS (ESI): 479.16 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethyl-benzenesulfonyl chloride and 4-cyclopropyl-aniline.

Sources & evidence

ORD record
ord-b636fcb672ba4df2af5e91e788bfb8e1
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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