2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → HCID 49800225, compound

HRID 2194065Notes

Reaction equation

HRID 2194065 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26].[F:31][C:32]([F:42])([F:41])[CH2:33][C:34]1[CH:40]=[CH:39][C:37]([NH2:38])=[CH:36][CH:35]=1>>[F:31][C:32]([F:41])([F:42])[CH2:33][C:34]1[CH:40]=[CH:39][C:37]([N:38]2[CH2:13][CH2:12][C:6]3([CH2:7][CH2:8][N:9]([S:25]([C:20]4[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=4[O:18][C:17]([F:30])([F:29])[F:16])(=[O:27])=[O:26])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:36][CH:35]=1

Participants

4

Reactant 3

HCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 148368584-(2,2,2-Trifluoroethyl)anilineHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49800225HCID 49800225, compound

Procedure

Off-white solid. MS (ESI): 537.12 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and 4-(2,2,2-trifluoro-ethyl)-aniline.

Sources & evidence

ORD record
ord-bd2cdae9dd934ff6950b9126f3488035
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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