2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → HCID 49800782, compound

HRID 2194076Notes

Reaction equation

HRID 2194076 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26].[F:31][C:32]([F:44])([F:43])[CH:33]([CH3:42])[O:34][C:35]1[N:40]=[CH:39][C:38]([NH2:41])=[CH:37][CH:36]=1>>[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:41]([C:38]3[CH:39]=[N:40][C:35]([O:34][CH:33]([CH3:42])[C:32]([F:44])([F:31])[F:43])=[CH:36][CH:37]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:27])=[O:26]

Participants

4

Reactant 3

HCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl esterHCID 66277354HCID 66277354, compound

Product 1

HCID 49800782HCID 49800782, compound

Procedure

Light brown solid. MS (ESI): 568.13 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and 6-(2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine.

Sources & evidence

ORD record
ord-44ac0a8395074d1fb5febbe421b3f84c
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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