4-(Trifluoromethoxy)aniline → HCID 49801074, compound

HRID 2194079Notes

Reaction equation

HRID 2194079 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH:16]1([CH2:20][S:21](Cl)(=[O:23])=[O:22])[CH2:19][CH2:18][CH2:17]1.[F:25][C:26]([F:36])([F:35])[O:27][C:28]1[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][CH:29]=1>>[CH:16]1([CH2:20][S:21]([N:9]2[CH2:8][CH2:7][C:6]3([C:4](=[O:5])[N:32]([C:31]4[CH:33]=[CH:34][C:28]([O:27][C:26]([F:25])([F:35])[F:36])=[CH:29][CH:30]=4)[CH2:13][CH2:12]3)[CH2:11][CH2:10]2)(=[O:23])=[O:22])[CH2:19][CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 55280140Cyclobutylmethanesulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49801074HCID 49801074, compound

Procedure

Light brown solid. MS (ESI): 447.15 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), cyclobutyl-methanesulfonyl chloride, 4-(trifluoromethoxy)-aniline.

Sources & evidence

ORD record
ord-b180785b0fd84a0ebf86571796166a2e
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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