4-(Trifluoromethoxy)aniline → HCID 49801356, compound

HRID 2194082Notes

Reaction equation

HRID 2194082 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH:16]1([S:19](Cl)(=[O:21])=[O:20])[CH2:18][CH2:17]1.[F:23][C:24]([F:34])([F:33])[O:25][C:26]1[CH:32]=[CH:31][C:29]([NH2:30])=[CH:28][CH:27]=1>>[CH:16]1([S:19]([N:9]2[CH2:8][CH2:7][C:6]3([C:4](=[O:5])[N:30]([C:29]4[CH:31]=[CH:32][C:26]([O:25][C:24]([F:23])([F:33])[F:34])=[CH:27][CH:28]=4)[CH2:13][CH2:12]3)[CH2:11][CH2:10]2)(=[O:21])=[O:20])[CH2:18][CH2:17]1

Participants

4

Reactant 3

HCID 6008484-(Trifluoromethoxy)anilineHCID 2760919Cyclopropanesulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester

Product 1

HCID 49801356HCID 49801356, compound

Procedure

White solid. MS (ESI): 419.12 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), cyclopropanesulfonyl chloride, 4-(trifluoromethoxy)-aniline.

Sources & evidence

ORD record
ord-d1fb35a9ef3a4c2e9a8580910137496a
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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