HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanesulfonyl chloride → 8-Cyclopropanesulfonyl-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanesulfonyl chloride | HCID 2760919 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Reactant | 4-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline | HCID 66277568 | — |
| Product | 8-Cyclopropanesulfonyl-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 49801358 | — |
Reaction Steps
White solid. MS (ESI): 447.15 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), cyclopropanesulfonyl chloride, 4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-27209a13bb314a00ae67cdc12352351e |
| Source note | uspto-grants-2012_12 |