2-Trifluoromethylbenzenesulphonyl chloride → 8-(2-Trifluoromethyl-benzenesulfonyl)-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

HRID 2194086Notes

Reaction equation

HRID 2194086 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:29])([F:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24](Cl)(=[O:26])=[O:25].[F:30][C:31]([F:43])([F:42])[CH:32]([CH3:41])[O:33][C:34]1[CH:39]=[CH:38][C:37]([NH2:40])=[CH:36][CH:35]=1>>[F:16][C:17]([F:29])([F:28])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=1[S:24]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:40]([C:37]3[CH:38]=[CH:39][C:34]([O:33][CH:32]([CH3:41])[C:31]([F:30])([F:42])[F:43])=[CH:35][CH:36]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:26])=[O:25]

Participants

4

Reactant 3

HCID 1366162-Trifluoromethylbenzenesulphonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl esterHCID 662775684-(2,2,2-Trifluoro-1-methyl-ethoxy)-aniline

Product 1

HCID 595779248-(2-Trifluoromethyl-benzenesulfonyl)-2-[4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one

Procedure

Light brown solid. MS (ESI): 551.14 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethyl-benzenesulfonyl chloride and 4-(2,2,2-trifluoro-1-methyl-ethoxy)-phenylamine.

Sources & evidence

ORD record
ord-72b80c3b9438487aa5c70fa1bc050867
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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