2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → HCID 59578027, compound

HRID 2194088Notes

Reaction equation

HRID 2194088 reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25](Cl)(=[O:27])=[O:26].[F:31][C:32]([F:44])([F:43])[CH2:33][CH2:34][O:35][C:36]1[CH:41]=[CH:40][C:39]([NH2:42])=[CH:38][CH:37]=1>>[F:16][C:17]([F:30])([F:29])[O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[S:25]([N:9]1[CH2:8][CH2:7][C:6]2([C:4](=[O:5])[N:42]([C:39]3[CH:40]=[CH:41][C:36]([O:35][CH2:34][CH2:33][C:32]([F:31])([F:43])[F:44])=[CH:37][CH:38]=3)[CH2:13][CH2:12]2)[CH2:11][CH2:10]1)(=[O:27])=[O:26]

Participants

4

Reactant 3

HCID 27772152-(Trifluoromethoxy)benzene-1-sulfonyl chlorideHCID 567539694-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl esterHCID 62056677HCID 62056677, compound

Product 1

HCID 59578027HCID 59578027, compound

Procedure

Off-white crystalline solid. MS (ESI): 567.2 (MH+). P This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and 4-(3,3,3-trifluoro-propoxy)-phenylamine.

Sources & evidence

ORD record
ord-fbbd683439e243ed92d5a694b19d457c
Source dataset
uspto-grants-2012_12
Patent number
US08329904B2

Reaction notes

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