HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethoxy)benzene-1-sulfonyl chloride → 2-[4-(2-Methoxy-ethyl)-phenyl]-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethoxy)benzene-1-sulfonyl chloride | HCID 2777215 | — |
| Reactant | 4-(2-Methoxyethyl)aniline | HCID 3020135 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Product | 2-[4-(2-Methoxy-ethyl)-phenyl]-8-(2-trifluoromethoxy-benzenesulfonyl)-2,8-diaza-spiro[4.5]decan-1-one | HCID 59578025 | — |
Reaction Steps
Light yellow solid. MS (ESI): 513.3 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-trifluoromethoxy-benzenesulfonyl chloride and 4-(2-methoxy-ethyl)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4e95509b3c804d70b6d1491558f2d0e2 |
| Source note | uspto-grants-2012_12 |