1-Propanesulfonyl chloride, 2-methyl- → 2-[4-(2-Methoxy-1,1-dimethyl-ethyl)-phenyl]-8-(2-methyl-propane-1-sulfonyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
C(O[C:4]([C:6]1([CH2:12][CH2:13]OC)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5])C.[CH3:16][CH:17]([CH3:23])[CH2:18][S:19](Cl)(=[O:21])=[O:20].[CH3:24][O:25][CH2:26][C:27]([C:30]1[CH:35]=[CH:34][C:33]([NH2:36])=[CH:32][CH:31]=1)([CH3:29])[CH3:28]>>[CH3:24][O:25][CH2:26][C:27]([C:30]1[CH:31]=[CH:32][C:33]([N:36]2[CH2:13][CH2:12][C:6]3([CH2:7][CH2:8][N:9]([S:19]([CH2:18][CH:17]([CH3:23])[CH3:16])(=[O:21])=[O:20])[CH2:10][CH2:11]3)[C:4]2=[O:5])=[CH:34][CH:35]=1)([CH3:29])[CH3:28]Participants
4
Procedure
Light yellow solid. MS (ESI): 437.24 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 2-methyl-propane-1-sulfonyl chloride, 4-(2-methoxy-1,1-dimethyl-ethyl)-phenylamine (synthesis: Ch. Tegley et al, WO 2005 021532).
Sources & evidence
- ORD record
- ord-78d10c6872d847c491892933964029be
- Source dataset
- uspto-grants-2012_12
- Patent number
- US08329904B2
Reaction notes
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