HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethylisoxazole-4-sulfonyl chloride → 8-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-[4-(2-methoxy-1,1-dimethyl-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethylisoxazole-4-sulfonyl chloride | HCID 2736319 | — |
| Reactant | 4-(2-Methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester | HCID 56753969 | — |
| Reactant | HCID 58721874 | HCID 58721874 | — |
| Product | 8-(3,5-Dimethyl-isoxazole-4-sulfonyl)-2-[4-(2-methoxy-1,1-dimethyl-ethyl)-phenyl]-2,8-diaza-spiro[4.5]decan-1-one | HCID 59578102 | — |
Reaction Steps
Off-white solid. MS (ESI): 476.22 (MH+). This example was prepared in analogy to example 1 step C) to D) from 4-(2-methoxy-ethyl)-piperidine-4-carboxylic acid ethyl ester (example 1 step B)), 3,5-dimethyl-isoxazole-4-sulfonyl chloride, 4-(2-methoxy-1,1-dimethyl-ethyl)-phenylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08329904B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-08942fa4e9584d0e8810e23760f553e7 |
| Source note | uspto-grants-2012_12 |